pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages for enhanced MDR reversal and chemotherapy

TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance (MDR) and as an anticancer agent for synergistic antitumor effects. However, the comparatively high critical micelle concentration (CMC), low drug loading (DL) and poor tumor target limit its further cl...

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Detalles Bibliográficos
Publicado en:Asian J Pharm Sci
Main Authors: Xu, Yong, Wang, Shi, Yang, Longshun, Dong, Yuhang, Zhang, Yafang, Yan, Guoqing, Tang, Rupei
Formato: Artigo
Idioma:Inglês
Publicado: Shenyang Pharmaceutical University 2021
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Original Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261081/
https://ncbi.nlm.nih.gov/pubmed/34276824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2021.01.002
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