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pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages for enhanced MDR reversal and chemotherapy

TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance (MDR) and as an anticancer agent for synergistic antitumor effects. However, the comparatively high critical micelle concentration (CMC), low drug loading (DL) and poor tumor target limit its further cl...

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Bibliografske podrobnosti
izdano v:Asian J Pharm Sci
Main Authors: Xu, Yong, Wang, Shi, Yang, Longshun, Dong, Yuhang, Zhang, Yafang, Yan, Guoqing, Tang, Rupei
Format: Artigo
Jezik:Inglês
Izdano: Shenyang Pharmaceutical University 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261081/
https://ncbi.nlm.nih.gov/pubmed/34276824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2021.01.002
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