Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

BACKGROUND: Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk of adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that the ubiquitin E3 ligase TRIM21 in...

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Bibliografiske detaljer
Udgivet i:	EBioMedicine
Main Authors:	Hou, Kai, Shen, Jianliang, Yan, Junrong, Zhai, Chuannan, Zhang, Jingxia, Pan, Ji-An, Zhang, Ye, Jiang, Yaping, Wang, Yongbo, Lin, Richard Z., Cong, Hongliang, Gao, Shenglan, Zong, Wei-Xing
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2021
Fag:	Research Paper
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8261003/ https://ncbi.nlm.nih.gov/pubmed/34233258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103456
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Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin

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