Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis. However, the molecular mechanism underlying this cardiotoxicity is yet...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Tadokoro, Tomonori, Ikeda, Masataka, Ide, Tomomi, Deguchi, Hiroko, Ikeda, Soichiro, Okabe, Kosuke, Ishikita, Akihito, Matsushima, Shouji, Koumura, Tomoko, Yamada, Ken-ichi, Imai, Hirotaka, Tsutsui, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253028/
https://ncbi.nlm.nih.gov/pubmed/32376803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132747
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