Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

Talin (TLN1) is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behavior of its multiple rod domains that modulate interactions with its binding partners. Cyclin-dependent kinase-1 (CDK1)...

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Publicat a:J Biol Chem
Autors principals: Gough, Rosemarie E., Jones, Matthew C., Zacharchenko, Thomas, Le, Shimin, Yu, Miao, Jacquemet, Guillaume, Muench, Ste P., Yan, Jie, Humphries, Jonathan D., Jørgensen, Claus, Humphries, Martin J., Goult, Benjamin T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260872/
https://ncbi.nlm.nih.gov/pubmed/34118235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100837
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