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Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages

The vinculin-mediated mechanosensing requires establishment of stable mechanical linkages between vinculin to integrin at focal adhesions and to cadherins at adherens junctions through associations with the respective adaptor proteins talin and α-catenin. However, the mechanical stability of these c...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Le, Shimin, Yu, Miao, Yan, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920023/
https://ncbi.nlm.nih.gov/pubmed/31897422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav2720
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