Genome-wide CRISPR/Cas9 screening in human iPS derived cardiomyocytes uncovers novel mediators of doxorubicin cardiotoxicity

Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering now facilitate the study of the molecular underpinnings of disease in relevant human cell types. Application of CRISPR/Cas9-based approaches for genome-scale functional screening in iPS-derived cells, however, ha...

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Vydáno v:Sci Rep
Hlavní autoři: Sapp, Valerie, Aguirre, Aitor, Mainkar, Gayatri, Ding, Jeffrey, Adler, Eric, Liao, Ronglih, Sharma, Sonia, Jain, Mohit
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260754/
https://ncbi.nlm.nih.gov/pubmed/34230586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92988-1
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