Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Prenylated indole alkaloids featuring spirooxindole rings possess a 3R or 3S carbon stereocenter, which determines the bioactivities of these compounds. Despite the stereoselective advantages of spirooxindole biosynthesis compared with those of organic synthesis, the biocatalytic mechanism for contr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Liu, Zhiwen, Zhao, Fanglong, Zhao, Boyang, Yang, Jie, Ferrara, Joseph, Sankaran, Banumathi, Venkataram Prasad, B. V., Kundu, Biki Bapi, Phillips, George N., Gao, Yang, Hu, Liya, Zhu, Tong, Gao, Xue
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260726/
https://ncbi.nlm.nih.gov/pubmed/34230497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24421-0
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