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Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane curvature to complete particle assembly. siRNA-mediated knoc...
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| Veröffentlicht in: | eLife |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8260224/ https://ncbi.nlm.nih.gov/pubmed/34114563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67321 |
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