Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane curvature to complete particle assembly. siRNA-mediated knoc...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Inamdar, Kaushik, Tsai, Feng-Ching, Dibsy, Rayane, de Poret, Aurore, Manzi, John, Merida, Peggy, Muller, Remi, Lappalainen, Pekka, Roingeard, Philippe, Mak, Johnson, Bassereau, Patricia, Favard, Cyril, Muriaux, Delphine
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Physics of Living Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260224/
https://ncbi.nlm.nih.gov/pubmed/34114563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67321
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