ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

Human genetics, biomarker, and animal studies implicate loss of function in bone morphogenetic protein (BMP) signaling and maladaptive transforming growth factor–β (TGFβ) signaling as drivers of pulmonary arterial hypertension (PAH). Although sharing common receptors and effectors with BMP/TGFβ, the...

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Publicado no:Sci Transl Med
Main Authors: Yung, Lai-Ming, Yang, Peiran, Joshi, Sachindra, Augur, Zachary M., Kim, Stephanie S. J., Bocobo, Geoffrey A., Dinter, Teresa, Troncone, Luca, Chen, Po-Sheng, McNeil, Megan E., Southwood, Mark, de Frias, Sergio Poli, Knopf, John, Rosas, Ivan O., Sako, Dianne, Pearsall, R. Scott, Quisel, John D., Li, Gang, Kumar, Ravindra, Yu, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259900/
https://ncbi.nlm.nih.gov/pubmed/32404506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaz5660
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