Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes

Macroautophagy dysregulation is implicated in multiple neurological disorders, such as Parkinson's disease. While autophagy pathways are heavily researched in heterologous cells and neurons, regulation of autophagy in the astrocyte, the most abundant cell type in the mammalian brain, is less we...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pan, Ping-Yue, Zhu, Justin, Rizvi, Asma, Zhu, Xinyu, Tanaka, Hikari, Dreyfus, Cheryl F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258991/
https://ncbi.nlm.nih.gov/pubmed/34126070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100873
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