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An in silico Framework of Cartilage Degeneration That Integrates Fibril Reorientation and Degradation Along With Altered Hydration and Fixed Charge Density Loss

Injurious mechanical loading of articular cartilage and associated lesions compromise the mechanical and structural integrity of joints and contribute to the onset and progression of cartilage degeneration leading to osteoarthritis (OA). Despite extensive in vitro and in vivo research, it remains un...

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Vydáno v:Front Bioeng Biotechnol
Hlavní autoři: Elahi, Seyed Ali, Tanska, Petri, Korhonen, Rami K., Lories, Rik, Famaey, Nele, Jonkers, Ilse
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258121/
https://ncbi.nlm.nih.gov/pubmed/34239859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2021.680257
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