An in silico Framework of Cartilage Degeneration That Integrates Fibril Reorientation and Degradation Along With Altered Hydration and Fixed Charge Density Loss

Injurious mechanical loading of articular cartilage and associated lesions compromise the mechanical and structural integrity of joints and contribute to the onset and progression of cartilage degeneration leading to osteoarthritis (OA). Despite extensive in vitro and in vivo research, it remains un...

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Bibliographische Detailangaben
Veröffentlicht in:Front Bioeng Biotechnol
Hauptverfasser: Elahi, Seyed Ali, Tanska, Petri, Korhonen, Rami K., Lories, Rik, Famaey, Nele, Jonkers, Ilse
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Bioengineering and Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258121/
https://ncbi.nlm.nih.gov/pubmed/34239859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2021.680257
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