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DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes
DNA glycosylases must distinguish the sparse damaged sites from the vast expanse of normal DNA bases. However, our understanding of the nature of nucleobase interrogation is still limited. Here, we show that hNEIL1 (human endonuclease VIII-like 1) captures base lesions via two competing states of in...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8257757/ https://ncbi.nlm.nih.gov/pubmed/34226550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24431-y |
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