Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies

Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA hypomethylating agents (HMA) constitute a class of drugs which are able to reverse DNA methylation, thereby triggering the re-programming of tumor cells. The first-generation HMA azacitidine and decitabine have n...

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Udgivet i:Leukemia
Main Authors: Stomper, Julia, Rotondo, John Charles, Greve, Gabriele, Lübbert, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257497/
https://ncbi.nlm.nih.gov/pubmed/33958699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-021-01218-0
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