Cellular context of IL-33 expression dictates impact on anti-helminth immunity

Interleukin-33 (IL-33) is a pleiotropic cytokine that can promote Type 2 inflammation, but also drives immunoregulation through Foxp3(+) Treg expansion. How IL-33 is exported from cells to serve this dual role in immunosuppression and inflammation remains unclear. Here, we demonstrate that the biolo...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Hung, Li-Yin, Tanaka, Yukinori, Herbine, Karl, Pastore, Christopher, Singh, Brenal, Ferguson, Annabel, Vora, Nisha, Douglas, Bonnie, Zullo, Kelly, Behrens, Ed, Tan, Tiffany Li Hui, Kohanski, Michael A., Bryce, Paul, Lin, Cailu, Kambayashi, Taku, Reed, Danielle R., Brown, Breann L., Cohen, Noam A., Herbert, De’Broski R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257082/
https://ncbi.nlm.nih.gov/pubmed/33188058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abc6259
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