Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of Parkinson’s disease (PD). Cell surface receptors such as lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) can preferentially bind α-syn in the amyloid over monomeric state to initi...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Shengnan, Liu, Yu-Qing, Jia, Chunyu, Lim, Yeh-Jun, Feng, Guoqin, Xu, Enquan, Long, Houfang, Kimura, Yasuyoshi, Tao, Youqi, Zhao, Chunyu, Wang, Chuchu, Liu, Zhenying, Hu, Jin-Jian, Ma, Meng-Rong, Liu, Zhijun, Jiang, Lin, Li, Dan, Wang, Renxiao, Dawson, Valina L., Dawson, Ted M., Li, Yan-Mei, Mao, Xiaobo, Liu, Cong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256039/
https://ncbi.nlm.nih.gov/pubmed/34172566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011196118
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