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HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic condit...

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Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Peng, Travis, Du, Shin-Yi, Son, Myoungsun, Diamond, Betty
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256008/
https://ncbi.nlm.nih.gov/pubmed/34108245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2106017118
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