Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain

A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs containing Glun2B subunits within the spinal cord and lacks motor side effects commonly associated with non-subunit-selective NMDAr antagonism, namely sedation and motor impairment. Spinally delivered agmatine has been...

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Vydáno v:Mol Pain
Hlavní autoři: Peterson, Cristina D, Kitto, Kelley F, Verma, Harsha, Pflepsen, Kelsey, Delpire, Eric, Wilcox, George L, Fairbanks, Carolyn A
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255568/
https://ncbi.nlm.nih.gov/pubmed/34210178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/17448069211029171
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