NGMA-6. Quantitative MGMT Promoter Methylation Index Indicates Non-Linear, Prognostic Effect in Glioblastoma

BACKGROUND: Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emerged as a clinically relevant prognostic marker in glioblastoma (GBM). Methylation of the MGMT promoter has been shown to increase chemotherapy efficacy. While traditionally reported as a binary marker...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Gibson, David, Ravi, Akshay, Rodriguez, Eduardo, Chang, Susan, Bush, Nancy, Taylor, Jennie, Clarke, Jennifer, Solomon, David, Scheffler, Aaron, Witte, John, Okada, Hideho, Berger, Mitchel, Chehab, Farid, Butowski, Nicholas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255458/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab070.021
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