Phase-2 Trial of palbociclib in adult patients with recurrent RB1-positive Glioblastoma

INTRODUCTION: Alterations in the CDK4/6 – RB signaling pathway are common causes of cell cycle dysregulation in many cancers, including glioblastoma. Palbociclib is an oral inhibitor of CDK4/6, which leads to phosphorylation of RB1 and cell-cycle arrest. We conducted a two-arm study evaluating effic...

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Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Taylor, Jennie W., Parikh, Mili, Phillips, Joanna J., James, C. David, Molinaro, Annette M., Butowski, Nicholas A., Clarke, Jennifer L., Oberheim-Bush, Nancy Ann, Chang, Susan M., Berger, Mitchel S., Prados, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239922/
https://ncbi.nlm.nih.gov/pubmed/30151703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-018-2977-3
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