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P09.59 Phase 2 trial of palbociclib in adult patients with recurrent Rb positive glioblastoma
Alterations in the CDK4/6 – RB signaling pathway are common causes of dysregulation of the cell cycle in many cancers, including glioblastoma. Palbociclib is an oral, highly selective, reversible inhibitor of CDK4/6, which leads to phosphorylation of RB and cell-cycle arrest. In a two-arm study, we...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5464153/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.314 |
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