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A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia
FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor prognosis. Multiple FLT3 inhibitors are in various stages of clinical evaluation. However, resistance to FLT3 inhibitors resulting from acquired point mutations in tyros...
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| Опубликовано в: : | J Hematol Oncol |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8255005/ https://ncbi.nlm.nih.gov/pubmed/34217323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-021-01098-y |
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