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A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor prognosis. Multiple FLT3 inhibitors are in various stages of clinical evaluation. However, resistance to FLT3 inhibitors resulting from acquired point mutations in tyros...

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Библиографические подробности
Опубликовано в: :J Hematol Oncol
Главные авторы: Wang, Peihong, Xiao, Xinhua, Zhang, Yuyin, Zhang, Baoyuan, Li, Donghe, Liu, Mingzhu, Xie, Xi, Liu, Chenxuan, Liu, Ping, Ren, Ruibao
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2021
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255005/
https://ncbi.nlm.nih.gov/pubmed/34217323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-021-01098-y
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