SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s disease

BACKGROUND: Human tauopathies including Alzheimer’s disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have been studi...

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Pubblicato in:Mol Neurodegener
Autori principali: Bichmann, Maria, Prat Oriol, Nuria, Ercan-Herbst, Ebru, Schöndorf, David C., Gomez Ramos, Borja, Schwärzler, Vera, Neu, Marie, Schlüter, Annabelle, Wang, Xue, Jin, Liang, Hu, Chenqi, Tian, Yu, Ried, Janina S., Haberkant, Per, Gasparini, Laura, Ehrnhoefer, Dagmar E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254302/
https://ncbi.nlm.nih.gov/pubmed/34215303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00468-x
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