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A Dual Role for the Histone Methyltransferase PR-SET7/SETD8 and Histone H4 Lysine 20 Monomethylation in the Local Regulation of RNA Polymerase II Pausing

RNA polymerase II (Pol II) promoter-proximal pausing plays a critical role in postinitiation transcriptional regulation at many metazoan genes. We showed recently that histone H4 lysine 16 acetylation (H4K16Ac), mediated by the MSL complex, facilitates the release of paused Pol II. In contrast, H4 l...

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Bibliografski detalji
Glavni autori: Kapoor-Vazirani, Priya, Vertino, Paula M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953257/
https://ncbi.nlm.nih.gov/pubmed/24459145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520783
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