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A Dual Role for the Histone Methyltransferase PR-SET7/SETD8 and Histone H4 Lysine 20 Monomethylation in the Local Regulation of RNA Polymerase II Pausing

RNA polymerase II (Pol II) promoter-proximal pausing plays a critical role in postinitiation transcriptional regulation at many metazoan genes. We showed recently that histone H4 lysine 16 acetylation (H4K16Ac), mediated by the MSL complex, facilitates the release of paused Pol II. In contrast, H4 l...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kapoor-Vazirani, Priya, Vertino, Paula M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953257/
https://ncbi.nlm.nih.gov/pubmed/24459145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520783
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