Upregulation of COX-2 and PGE(2) Induced by TNF-α Mediated Through TNFR1/MitoROS/PKCα/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts

PURPOSE: Tumor necrosis factor-α (TNF-α) has been shown to exert as a pathogenic factor in cardiac fibrosis and heart failure which were associated with the up-regulation of cyclooxygenase (COX)-2/prostaglandin E(2) (PGE(2)) axis. However, whether TNF-α-induced COX-2/PGE(2) upregulation mediated thr...

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Detalhes bibliográficos
Publicado no:J Inflamm Res
Main Authors: Yang, Chuen-Mao, Yang, Chien-Chung, Hsiao, Li-Der, Yu, Chia-Ying, Tseng, Hui-Ching, Hsu, Chih-Kai, Situmorang, Jiro Hasegawa
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254141/
https://ncbi.nlm.nih.gov/pubmed/34234507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S313665
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