The antiviral enzyme viperin inhibits cholesterol biosynthesis

Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (Virus Inhibitory Protein, Endoplasmic Reticulum-associated, Interferon iNducible) is an endoplasmic r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Grunkemeyer, Timothy J., Ghosh, Soumi, Patel, Ayesha M., Sajja, Keerthi, Windak, James, Basrur, Venkatesha, Kim, Youngsoo, Nesvizhskii, Alexey I., Kennedy, Robert T., Marsh, E. Neil G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254119/
https://ncbi.nlm.nih.gov/pubmed/34029588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100824
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