Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding

The serotonin transporter (SERT) shapes serotonergic neurotransmission by retrieving its eponymous substrate from the synaptic cleft. Ligands that discriminate between SERT and its close relative, the dopamine transporter DAT, differ in their association rate constant rather than their dissociation...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Esendir, Eray, Burtscher, Verena, Coleman, Jonathan A., Zhu, Rong, Gouaux, Eric, Freissmuth, Michael, Sandtner, Walter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253976/
https://ncbi.nlm.nih.gov/pubmed/34118233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100863
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