NAD(P)HX epimerase downregulation promotes tumor progression through ROS/HIF‐1α signaling in hepatocellular carcinoma

Reactive oxygen species (ROS) derived from aberrant tumor metabolism could contribute to tumor invasion and metastasis. NAD(P)HX Epimerase (NAXE), an epimerase that allows the repair of damaged forms of antioxidant NADPH, is a potential cellular ROS scavenger and its role in tumor development is sti...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Sun, Bo, Yu, Lei, Xu, Cong, Li, Yi‐Ming, Zhao, Yan‐Rong, Cao, Mo‐Mo, Yang, Lian‐Yue
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253267/
https://ncbi.nlm.nih.gov/pubmed/33932069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14925
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