Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function

NAD(P)H-hydrate epimerase (EC 5.1.99.6) is known to help repair NAD(P)H hydrates (NAD(P)HX), which are damage products existing as R and S epimers. The S epimer is reconverted to NAD(P)H by a dehydratase; the epimerase facilitates epimer interconversion. Epimerase deficiency in humans causes a letha...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Main Authors: Niehaus, Thomas D., Elbadawi-Sidhu, Mona, Huang, Lili, Prunetti, Laurence, Gregory, Jesse F., de Crécy-Lagard, Valérie, Fiehn, Oliver, Hanson, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938422/
https://ncbi.nlm.nih.gov/pubmed/29654173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20180223
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