Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer

To conquer the drug resistance of tumors and the poor solubility of paclitaxel (PTX), two PTX-cell-penetrating peptide conjugates (PTX-CPPs), PTX-TAT and PTX-LMWP, were synthesized and evaluated for the first time. Compared with free PTX, PTX-CPPs displayed significantly enhanced cellular uptake, el...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Duan, Ziqing, Chen, Cuitian, Qin, Jing, Liu, Qi, Wang, Qi, Xu, Xinchun, Wang, Jianxin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253140/
https://ncbi.nlm.nih.gov/pubmed/28468542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1321060
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