Classification of high‐grade cervical intraepithelial neoplasia by p16(ink4a), Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management

High‐grade cervical intraepithelial neoplasia (CIN2 and CIN3) represents a heterogeneous disease with varying cancer progression risks. Biomarkers indicative for a productive human papillomavirus (HPV) infection (HPV E4) and a transforming HPV infection (p16(ink4a), Ki‐67 and host‐cell DNA methylati...

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Dades bibliogràfiques
Publicat a:Int J Cancer
Autors principals: Vink, Frederique J., Dick, Stèfanie, Heideman, Daniëlle A. M., De Strooper, Lise M. A., Steenbergen, Renske D. M., Lissenberg‐Witte, Birgit I., Floore, Arno, Bonde, Jesper H., Oštrbenk Valenčak, Anja, Poljak, Mario, Petry, Karl U., Hillemanns, Peter, van Trommel, Nienke E., Berkhof, Johannes, Bleeker, Maaike C. G., Meijer, Chris J. L. M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2021
Matèries:
Tumor Markers and Signatures
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252755/
https://ncbi.nlm.nih.gov/pubmed/33729551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33566
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