Classification of high‐grade cervical intraepithelial neoplasia by p16(ink4a), Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management

High‐grade cervical intraepithelial neoplasia (CIN2 and CIN3) represents a heterogeneous disease with varying cancer progression risks. Biomarkers indicative for a productive human papillomavirus (HPV) infection (HPV E4) and a transforming HPV infection (p16(ink4a), Ki‐67 and host‐cell DNA methylati...

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發表在:Int J Cancer
Main Authors: Vink, Frederique J., Dick, Stèfanie, Heideman, Daniëlle A. M., De Strooper, Lise M. A., Steenbergen, Renske D. M., Lissenberg‐Witte, Birgit I., Floore, Arno, Bonde, Jesper H., Oštrbenk Valenčak, Anja, Poljak, Mario, Petry, Karl U., Hillemanns, Peter, van Trommel, Nienke E., Berkhof, Johannes, Bleeker, Maaike C. G., Meijer, Chris J. L. M.
格式: Artigo
語言:Inglês
出版: John Wiley & Sons, Inc. 2021
主題:
Tumor Markers and Signatures
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252755/
https://ncbi.nlm.nih.gov/pubmed/33729551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33566
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