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Avidity optimization of a MAGE‐A1‐specific TCR with somatic hypermutation
A T‐cell receptor (TCR) with optimal avidity to a tumor antigen can be used to redirect T cells to eradicate cancer cells via adoptive cell transfer. Cancer testis antigens (CTAs) are attractive targets because they are expressed in the testis, which is immune‐privileged, and in the tumor. However,...
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| Publicado no: | Eur J Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8252751/ https://ncbi.nlm.nih.gov/pubmed/33835499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.202049007 |
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