mRNA-transfected Dendritic Cells Expressing Polypeptides That Link MHC-I Presentation to Constitutive TLR4 Activation Confer Tumor Immunity

Recently, we have developed a novel genetic platform for improving dendritic cell (DC) induction of peptide-specific CD8 T cells, based on membrane-anchored β(2)-microglobulin (β(2)m) linked to a selected antigenic peptide at its N-terminus and to the cytosolic domain of toll-like receptor (TLR)4 C-...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Cafri, Gal, Sharbi-Yunger, Adi, Tzehoval, Esther, Alteber, Zoya, Gross, Tamar, Vadai, Ezra, Margalit, Alon, Gross, Gideon, Eisenbach, Lea
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817861/
https://ncbi.nlm.nih.gov/pubmed/25997427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.90
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