Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of the apoptotic signalling enzyme caspase‐9, using short DNA elements as modular recruitment domains. Caspase‐9 assembly and activation on the HTHP platform due to enhanced proximity is fol...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Mashima, Tsuyoshi, Rosier, Bas J. H. M., Oohora, Koji, de Greef, Tom F. A., Hayashi, Takashi, Brunsveld, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252739/
https://ncbi.nlm.nih.gov/pubmed/33725379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202102160
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