Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of the apoptotic signalling enzyme caspase‐9, using short DNA elements as modular recruitment domains. Caspase‐9 assembly and activation on the HTHP platform due to enhanced proximity is fol...

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Foilsithe in:Angew Chem Int Ed Engl
Main Authors: Mashima, Tsuyoshi, Rosier, Bas J. H. M., Oohora, Koji, de Greef, Tom F. A., Hayashi, Takashi, Brunsveld, Luc
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
Ábhair:
Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252739/
https://ncbi.nlm.nih.gov/pubmed/33725379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202102160
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