Probing activation‐driven changes in coagulation factor IX by mass spectrometry

BACKGROUND: Activated factor IX (FIXa) is an inefficient enzyme that needs activated factor VIII (FVIII) for full activity. Recently, we identified a network of FVIII‐driven changes in FIXa employing hydrogen‐deuterium eXchange mass spectrometry (HDX‐MS). Some changes also occurred in active‐site in...

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Bibliografiset tiedot
Julkaisussa:J Thromb Haemost
Päätekijät: Freato, Nadia, van Alphen, Floris P. J., Boon‐Spijker, Mariëtte, van den Biggelaar, Maartje, Meijer, Alexander B., Mertens, Koen, Ebberink, Eduard H. T. M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
Aiheet:
HAEMOSTASIS
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252100/
https://ncbi.nlm.nih.gov/pubmed/33687765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15288
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