Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking

Factor VIII C-domains are believed to have specific functions in cofactor activity and in interactions with von Willebrand factor. We have previously shown that factor VIII is co-targeted with von Willebrand factor to the Weibel-Palade bodies in blood outgrowth endothelial cells, even when factor VI...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Ebberink, Eduard H.T.M., Bouwens, Eveline A.M., Bloem, Esther, Boon-Spijker, Mariëtte, van den Biggelaar, Maartje, Voorberg, Jan, Meijer, Alexander B., Mertens, Koen
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5395109/
https://ncbi.nlm.nih.gov/pubmed/28057741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.153163
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