D’ domain region Arg782-Cys799 of von Willebrand factor contributes to factor VIII binding

In the complex with von Willebrand factor (VWF) factor VIII (FVIII) is protected from rapid clearance from circulation. Although it has been established that the FVIII binding site resides in the N-terminal D’-D3 domains of VWF, detailed information about the amino acid regions that contribute to FV...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Przeradzka, Małgorzata A., van Galen, Josse, Ebberink, Eduard H. T. M., Hoogendijk, Arie J., van der Zwaan, Carmen, Mertens, Koen, van den Biggelaar, Maartje, Meijer, Alexander B.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271574/
https://ncbi.nlm.nih.gov/pubmed/31558672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.221994
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