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A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia
Targeting protein‐protein interactions (PPIs) with small‐molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin is encoded by the MEN1 tumor suppressor, but acts as an essentia...
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| Publicado en: | ChemMedChem |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8252030/ https://ncbi.nlm.nih.gov/pubmed/33534953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000972 |
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