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Comprehensive Analysis of Binding Sites in Tubulin
Tubulin plays essential roles in vital cellular activities and is the target of a wide range of proteins and ligands. Here, using a combined computational and crystallographic fragment screening approach, we addressed the question of how many binding sites exist in tubulin. We identified 27 distinct...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8251789/ https://ncbi.nlm.nih.gov/pubmed/33951246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202100273 |
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