Functional Genomic Analysis of a RUNX3 Polymorphism Associated With Ankylosing Spondylitis

OBJECTIVE: To investigate the functional consequences of the single‐nucleotide polymorphism rs4648889 in a putative enhancer upstream of the RUNX3 promoter associated with susceptibility to ankylosing spondylitis (AS). METHODS: Using nuclear extracts from Jurkat cells and primary human CD8+ T cells,...

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Bibliografske podrobnosti
izdano v:Arthritis Rheumatol
Main Authors: Vecellio, Matteo, Chen, Liye, Cohen, Carla J., Cortes, Adrian, Li, Yan, Bonham, Sarah, Selmi, Carlo, Brown, Matthew A., Fischer, Roman, Knight, Julian C., Wordsworth, B. Paul
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Spondyloarthritis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251554/
https://ncbi.nlm.nih.gov/pubmed/33369221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41628
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