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RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?

Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2...

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Foilsithe in:Front Immunol
Main Authors: Vecellio, Matteo, Cohen, Carla J., Roberts, Amity R., Wordsworth, Paul B., Kenna, Tony J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335330/
https://ncbi.nlm.nih.gov/pubmed/30687330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03132
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