An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

OBJECTIVES: To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region. METHODS: We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodell...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Roberts, Amity R, Vecellio, Matteo, Chen, Liye, Ridley, Anna, Cortes, Adrian, Knight, Julian C, Bowness, Paul, Cohen, Carla J, Wordsworth, B Paul
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136719/
https://ncbi.nlm.nih.gov/pubmed/26916345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208640
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