Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

Eukaryotic mRNAs are emerging modalities for protein replacement therapy and vaccination. Their 5′ cap is important for mRNA translation and immune response and can be naturally methylated at different positions by S‐adenosyl‐l‐methionine (AdoMet)‐dependent methyltransferases (MTases). We report on...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: van Dülmen, Melissa, Muthmann, Nils, Rentmeister, Andrea
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8250829/
https://ncbi.nlm.nih.gov/pubmed/33751748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202100352
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