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Aggregation is a Context-Dependent Constraint on Protein Evolution

Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important goal. Here, we analysed two deep mutational s...

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Podrobná bibliografie
Vydáno v:Front Mol Biosci
Hlavní autoři: Monti, Michele, Armaos, Alexandros, Fantini, Marco, Pastore, Annalisa, Tartaglia, Gian Gaetano
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249573/
https://ncbi.nlm.nih.gov/pubmed/34222334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.678115
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