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Aggregation is a Context-Dependent Constraint on Protein Evolution

Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important goal. Here, we analysed two deep mutational s...

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Dettagli Bibliografici
Pubblicato in:Front Mol Biosci
Autori principali: Monti, Michele, Armaos, Alexandros, Fantini, Marco, Pastore, Annalisa, Tartaglia, Gian Gaetano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249573/
https://ncbi.nlm.nih.gov/pubmed/34222334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.678115
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